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EPIC CODE: LAB514 Parietal Cell Antibodies, IgG, Serum

Additional Codes

Sunquest:  PCASM
Mayo:         PCAB
Previously: ARUP 0050596

Reporting Name

Parietal Cell Ab, IgG, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.45 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reference Values

Negative: ≤20.0 Units

Equivocal: 20.1-24.9 Units

Positive: ≥25.0 Units 

Reference values apply to all ages.

Day(s) Performed

Tuesday, Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PCAB Parietal Cell Ab, IgG, S 40960-7


Result ID Test Result Name Result LOINC Value
PCAB Parietal Cell Ab, IgG, S 40960-7


The presence of immune complexes or other immunoglobulin aggregates in the patient specimen may cause an increased nonspecific binding and produce false-positive results in this assay.


A negative result does not rule out the presence of parietal cell antibodies; the concentration of antibody may be below the detection limit of the assay.


A positive result only indicates the presence of antibody to H(+)/K(+) ATPase and does not necessarily indicate the presence of autoimmune disease or other diseases.


The assay performance has not been established for pediatric patients.


Results of this assay should be used in conjunction with clinical findings and other serological tests.


The assay performance characteristics have not been established for matrices other than serum.

Clinical Reference

1. Toh BH, Van Driel IR, Gleeson PA: Pernicious anemia. N Eng J Med. 1997;337(20):1441-1448

2. Bizzaro N, Antico A: Diagnosis and classification of pernicious anemia. Autoimmun Rev. 2014;13(4-5):565-568

3. Toh BH: Pathophysiology and laboratory diagnosis of pernicious anemia. Immunol Res. 2017;65(1):326-330

4. Lenti MV, Rugge M, Lahner E, et al: Autoimmune gastritis. Nat Rev Dis Primers. 2020 Jul 9;6(1):56

6. Oo TH: Diagnostic difficulties in pernicious anemia. Discov Med. 2019;28(155):247-253

Report Available

1 to 4 days

Specimen Retention Time

14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK
Heat-treated specimen Reject

NY State Approved


Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Secondary ID