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EPIC CODE: LAB424 Phencyclidine Confirmation, Random, Urine

Additional Codes

Sunquest:  PCPUM
Mayo:         PCPU
Previously: ARUP 2010462

Reporting Name

Phencyclidine Confirmation, U

Useful For

Detection of drug abuse involving phencyclidine (street names: angel dust, hog, or angel hair)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Ordering Guidance


1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order PCPX / Phencyclidine Confirmation, Chain of Custody, Random, Urine

2. If urine creatinine is required or adulteration of the sample is suspected, order ADULT / Adulterants Survey, Random, Urine.

3. Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.



Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Container Tube: Plastic, 10 mL urine tube

Specimen Volume: 10 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Additional Information:

1. No specimen substitutions.

2. STATS are not accepted for this test.


Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reference Values

Negative

Cutoff concentrations

Phencyclidine by GC-MS: <10 ng/mL

Day(s) Performed

Tuesday, Thursday

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83992

G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PCPU Phencyclidine Confirmation, U 16254-5

 

Result ID Test Result Name Result LOINC Value
6673 Phencyclidine-by GC/MS 16254-5
21192 Phencyclidine Interpretation 69050-3
21193 Chain of Custody 77202-0

Clinical Information

Phencyclidine (PCP) is a drug of abuse. This compound affects diverse neural pathways and interacts with cholinergic, adrenergic, GABA-secreting, serotoninergic, opiate neuronal receptors, and gamma receptors. It has analgesic, anesthetic, and stimulatory effects, yielding bizarre behavior, ranging from depression through catatonia, euphoria, violent rage, and hallucinations. Most fatalities result from its hypertensive effect.

 

Diagnosis of PCP usage depends on drug screening. PCP is excreted in the urine.

Interpretation

The presence of phencyclidine (PCP) in urine is a strong indicator that the patient has used PCP.

Cautions

Urine phencyclidine (PCP) may be undetectable at alkaline pH.

Clinical Reference

1. Schuster DI, Arnold FJ, Murphy RB: Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain. Brain Res 1995;670:14-28

2. Bayorh MA, Zokowska-Grojec A, Palkovits M, Kopin IJ: Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei. Brain Res 1984;321:315-318

3. Baselt RC: Disposition of Toxic Drugs and Chemicals in Man. 11th edition. Biomedical Publications, 2017

Method Description

The specimen is analyzed by gas chromatography/mass spectrometry.(Unpublished Mayo method)

Report Available

2 to 8 days

Specimen Retention Time

14 days

Reject Due To

Gross hemolysis OK
Gross icterus OK

NY State Approved

Yes

Method Name

Gas Chromatography-Mass Spectrometry (GC-MS) Confirmation with Quantitation

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.