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HelpEPIC CODE: LAB424 Phencyclidine Confirmation, Random, Urine
Additional Codes
Sunquest: PCPUM
Mayo: PCPU
Previously: ARUP 2010462
Reporting Name
Phencyclidine Confirmation, UUseful For
Detection of drug abuse involving phencyclidine (street names: angel dust, hog, or angel hair)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
UrineOrdering Guidance
1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order PCPX / Phencyclidine Confirmation, Chain of Custody, Random, Urine
2. If urine creatinine is required or adulteration of the sample is suspected, order ADULT / Adulterants Survey, Random, Urine.
3. Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container Tube: Plastic, 10 mL urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Additional Information:
1. No specimen substitutions.
2. STATS are not accepted for this test.
Specimen Minimum Volume
1.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 72 hours |
Reference Values
Negative
Cutoff concentrations
Phencyclidine by GC-MS: <10 ng/mL
Day(s) Performed
Monday, Wednesday
Test Classification
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83992
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PCPU | Phencyclidine Confirmation, U | 16254-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 6673 | Phencyclidine-by GC/MS | 16254-5 |
| 21192 | Phencyclidine Interpretation | 69050-3 |
| 21193 | Chain of Custody | 77202-0 |
Clinical Information
Phencyclidine (PCP) is a drug of abuse. This compound affects diverse neural pathways and interacts with cholinergic, adrenergic, GABA-secreting, serotoninergic, opiate neuronal receptors, and gamma receptors. It has analgesic, anesthetic, and stimulatory effects, yielding bizarre behavior, ranging from depression through catatonia, euphoria, violent rage, and hallucinations. Most fatalities result from its hypertensive effect.
Diagnosis of PCP usage depends on drug screening. PCP is excreted in the urine.
Interpretation
The presence of phencyclidine (PCP) in urine is a strong indicator that the patient has used PCP.
Cautions
Urine phencyclidine (PCP) may be undetectable at alkaline pH.
Clinical Reference
1. Schuster DI, Arnold FJ, Murphy RB: Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain. Brain Res 1995;670:14-28
2. Bayorh MA, Zokowska-Grojec A, Palkovits M, Kopin IJ: Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei. Brain Res 1984;321:315-318
3. Baselt RC: Disposition of Toxic Drugs and Chemicals in Man. 11th edition. Biomedical Publications, 2017
Method Description
The specimen is analyzed by gas chromatography/mass spectrometry.(Unpublished Mayo method)
Report Available
3 to 7 daysSpecimen Retention Time
14 daysReject Due To
| Gross hemolysis | OK |
| Gross icterus | OK |
NY State Approved
YesMethod Name
Gas Chromatography-Mass Spectrometry (GC-MS) Confirmation with Quantitation
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.