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EPIC CODE: LAB2811 Drug Screen, Prescription/Over the Counter, Serum

Additional Codes

Sunquest: DSCRM
Mayo:        DSS

Reporting Name

Drug Screen, Prescription/OTC, S

Useful For

Detection and identification of prescription or over the counter drugs frequently found in drug overdose or used with a suicidal intent


Qualitatively identifying drugs present in the specimen; quantification of identified drugs, when available, may be performed upon client request


This test is not intended for therapeutic drug monitoring or compliance testing.


This test is not intended for use in employment-related testing.


This test is not useful for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, amphetamine type stimulants.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red

Ordering Guidance

For chain-of-custody testing, order DSSX / Drug Screen, Prescription/Over the Counter, Chain of Custody, Serum.

Specimen Required

Collection Container/Tube: Red top (serum gel/SST tubes are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 2.75 mL

Collection Instructions: Collect specimen, centrifuge and aliquot serum into plastic vial within 2 hours of collection.

Specimen Minimum Volume

1.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  3 hours

Special Instructions

Reference Values

Drugs detected are presumptive. Additional testing may be required to confirm the presence of any drugs detected.

Day(s) Performed

Monday through Sunday

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
DSS Drug Screen, Prescription/OTC, S 20785-2


Result ID Test Result Name Result LOINC Value
31072 Drugs detected: 20785-2
31168 Chain of Custody 77202-0

Clinical Information

This test looks for a broad spectrum of prescription and over-the-counter (OTC) drugs. It is designed to detect drugs that have toxic effects, as well as known antidotes or active therapies that a clinician can initiate to treat the toxic effect. The test is intended to help physicians manage an apparent overdose or intoxicated patient, or to determine if a specific set of symptoms might be due to the presence of drugs. This test is not appropriate for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, and amphetamine type stimulants.


Drugs of toxic significance that are not detected by this test are: digoxin, lithium, and many drugs of abuse or illicit drugs, some benzodiazepines, and some opioids.


For more information see Emergency/Overdose for detection limits for drugs detected in this test.


The drugs that are detected by this test are listed in Emergency/Overdose.


The pharmacology of each drug determines how the test should be interpreted. A detailed discussion of each drug is beyond the scope of this text. If you wish to have a report interpreted, call 800-533-1710 and ask for a toxicology consultant.


Each report will indicate the drugs detected.


Specimens collected in serum gel tubes are not acceptable, as the drug/analyte can absorb on the gel and lead to falsely decreased concentrations.

Clinical Reference

1. Langman LJ, Bechtel LK, Meier BM, Holstege C: Clinical toxicology. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:1294

2. Baselty RC: Disposition of Toxic Drugs and Chemicals in Man. 10th ed. Biomedical Publications; 2014

Method Description

Screening is by gas chromatography-mass spectroscopy.(Unpublished Mayo method)

Report Available

3 days

Specimen Retention Time

2 weeks

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

NY State Approved


Method Name

Gas Chromatography-Mass Spectrometry (GC-MS)

Secondary ID



If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.